CRISPR/Cas9 Mini Model
Give your students a hands-on exploration of the next generation in genetic engineering! We are thrilled to be able to offer an affordable version of the 3D-printed Cas9 component of the CRISPR gene editing technology.
Jennifer Doudna, PhD, Professor at UC-Berkeley and Executive Director of the Innovative Genomics Initiative (IGI), is one of the pioneers of the CRISPR/Cas9 technique, which allows researchers to make specific changes to the genetic code of cells and organisms. 3D Molecular Designs designed and built the model for Dr. Doudna with Jacob Corn, PhD, Scientific Director of the IGI. The front segment of the surface model (white) detaches, allowing students a closer look at the guide RNA (orange) and two strands of DNA (light blue and dark blue) inside. The DNA and RNA can be removed from the 11'' model. The green section is the Protospacer Adjacent Motif, a specific sequence of 3-5 DNA nucleotides known as the PAM sequence. The PAM sequence must be present in double-stranded DNA in order for the cas9 protein to cut the DNA properly.
The 5'' CRISPR model 3D printed in plaster should be handled with care. It will break if dropped, held tightly or handled roughly. The 5'' and 11'' nylon models are more resilient but will break if held tightly or handled roughly. They are based on a custom PDB file.