Model CRISPR Biology and CRISPR-Cas9 Biotechnology!

NEW CRISPR Adaptive Immunity Kit©

Discover how bacteria remember past viral infections and activate their CRISPR systems to search for and destroy the remembered virus’ DNA - preventing infection. This introduction to CRISPR biology will prepare your students to  understand how the Cas9 protein works. 

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NEW Making the Cut with CRISPR-Cas9©

Model how the Cas9 protein is programmed with RNA to search for and identify specific sequences of DNA before making the double-stranded cut. Explore and discuss how Cas9 is being engineered with new features that make it a useful tool for editing the human genome.

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With the CRISPR Adaptive Immunity Kit's engaging foam pieces, your students can:

  • Build the bacteria’s CRISPR array which includes Cas9, tracr, spacer and repeats.
  • Detect the presence of viral double-stranded DNA.
  • Integrate a short fragment of this viral genome into the bacteria’s CRISPR array.
  • Express the CRISPR array to create the Cas9 proteins and the guide RNA.

With Making the Cut with CRISPR-Cas9's colorful foam pieces and placemat your students can:

  • Build a schematic model of the CRISPR-Cas9 RNA-guided endonuclease, including the viral double-stranded DNA and dual guide RNA.
  • Understand how the Cas9 protein binds to a specific sequence of viral double-stranded DNA at a PAM site - and cuts it.
  • Demonstrate how that cut destroys viral genome and prevents the infection of bacteria.
  • And much more!

CRISPR-Cas9 Mini Model

 

Explore the Cas9 component of the CRISPR gene editing technology with this 3D printed model we built for Dr. Jennifer Doudna, winner of the 2020 Nobel Prize in Chemistry as a pioneer of the CRISPR-Cas9 technique. LEARN MORE