Synapse Construction Kit©

Engage your classroom with hands-on modeling of neuronal communication! Students can use the colorful foam pieces in the Synapse Construction Kit© to:

  • Discover how the resting potential of a neuron is established.
  • Demonstrate the propagation of an action potential down an axon.
  • Simulate the action of the sodium-potassium pump in resetting the resting potential.
  • Explore the effects of neurotransmitters acetylcholine, dopamine and GABA on a post synaptic neuron.
  • Model cholinergic, dopaminergic and GABAergic synapses.
  • Compare and contrast metabotropic and ionontropic receptors.
  • Analyze the impact of various substances such as nicotine, cocaine, sarin gas and propofol on neuronal signaling.
  • And much more!


Kit Contents

Synapse Construction Kit© 1-Group
Membranes 22
Synaptotagmin 1
SNAP/SNARE Proteins 2
Toxins 2
Gated Sodium Channels 4
Potassium Leak Channels 4
Gated Potassium Channels 4
Gated Calcium Channel 1
G-Protein Coupled Receptor 1
Transport Proteins 2
Sodium/Potassium Pumps 2
Acetylcholine Receptor 1
GABA Receptor 1
Acetylcholinesterase 1
Acetylcholines 7
Dopamines 7
Sarins 2
Cocaines 2
Propofols 2
Nicotines 2
ADP and Pi 1
Potassium Ions 30
Chloride Ions 12
Sodium Ions 30
Calcium Ions 8

















Please allot approximately 60 minutes to put together your first kit and 45 minutes for each additional kit (if you have more than one).

Synapse Construction Kit Contents and Assembly

Find information about the contents of your Synapse Construction Kit© and directions for assembling the pieces.


Synapse Construction Kit Neurotransmission and Perturbance

Have your students model the events of neurotransmission at a cholinergic, dopaminergic and/or GABAergic synapse. Then, model a perturbance in a cholinergic, dopaminergic and/or GABAergic synapse.


Synapse Construction Kit Teacher Notes

This activity guide will help you consider different ways you may use these materials. We encourage you to modify these lessons and activities to meet the learning objectives and needs of your specific students.


Synapse Construction Kit Videos

Explore videos to enhance your use of the Synapse Construction Kit and classroom study of neurons and synapses.


Synapse Construction Kit Neuronal Synapse Guides

Introduce your students to dopaminergic, cholinergic and/or GABAergic neuronal synapses.


Synapse Construction Kit Next Generation Science Standards

Synapse Construction Kit Connections to: A Framework for K-12 Science Education Practices, Crosscutting Concepts, and Core Ideas


Synapse Construction Kit Resting and Action Potentials

Set up axonal membranes and model neuronal resting potential and action potential.


Product Details


Grade Level

High School

Students per Group



Choking Hazard
Science Education Product
California Proposition 65

List Price

Synapse Construction Kit©
    $129 (SCK-01)
    $375 (SCK-03)
    $715 (SCK-06)

Disinfecting Kits

Teacher Tips

Assemble kit(s) on poster board or a large piece of cardboard to make transportation easier.

Assemble kit(s) on a large dry erase board or butcher paper so students can draw additional pieces.

Colors may fade. Consider storing foam kits in a dark location such as a closet, cabinet or drawer.

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