Dr. Goodsell creates cellular landscapes that accurately illustrate the size, shape, and distribution of proteins in their natural environment of the cell. These unique watercolor images connect the molecular world, inferred by X-ray crystallography and NMR spectroscopy, with the cellular world, observed by light and electron microscopy.
The Panorama© and Grand Panorama© illustrate how DNA in the nucleus is wrapped around histones, which forms nucleosomes. RNA polymerase unwraps the DNA and makes mRNA, which is delivered through nuclear pore complexes to ribosomes where antibody proteins are made and delivered into the endoplasmic reticulum. Vesicles carry the protein through the Golgi, and kinesin motor proteins pull the antibodies to the cell membrane – a wonderful example of the immunology of your flu shot.