Acetylcholinesterase Active Site Cube© Connections to: A Framework for K-12 Science Education Practices, Crosscutting Concepts, and Core Ideas*

Dimension 1. Scientific and Engineering Practices

1. Asking questions (for science) and defining problems (for engineering)
2. Developing and using models
3. Planning and carrying out investigations
4. Analyzing and interpreting data
6. Constructing explanations (for science) and designing solutions (for engineering)

Dimension 2. Crosscutting Concepts

1. Patterns
2. Cause and effect: Mechanism and explanation
6. Structure and function
7. Stability and change

Dimension 3. Disciplinary Core Ideas

Physical Sciences

PS1: Matter and Its Interactions

PS1.A: Structure and Properties of Matter
PS1.B: Chemical Reactions
PS1.C: Nuclear Processes

PS2: Motion and Stability: Forces and Interactions

PS2.A: Forces and Motion
PS2.B: Types of Interactions
PS2.C: Stability and Instability in Physical Systems

Life Sciences

LS1: From Molecules to Organisms: Structures and Processes

LS1.A: Structure and Function
LS1.D: Information Processing

LS2: Ecosystems: Interactions, Energy, and Dynamics

LS2.A: Interdependent Relationships in Ecosystems
LS2.C: Ecosystem Dynamics, Functioning, and Resilience


LS3: Heredity: Inheritance and Variation of Traits

LS3.A: Inheritance of Traits
LS3.B: Variation of Traits

LS4: Biological Evolution: Unity and Diversity

LS4.A: Evidence of Common Ancestry and Diversity
LS4.B: Natural Selection
LS4.C: Adaptation
LS4.D: Biodiversity and Humans

Engineering, Technology and Applications of Science

ETS2: Links Among Engineering, Technology, Science, and Society

ETS2.A: Interdependence of Science, Engineering, and Technology
ETS2.B: Influence of Engineering, Technology, and Science on Society and the Natural World

*The NSTA Reader’s Guide to A Framework for K-12 Science Education, National Research Council (NRC), 2011. A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas. Washington, D.C.: National Academies Press.