CRISPR/Cas9 Mini Model

CRISPR/Cas9 Mini Model

The Cas9 component of the CRISPR gene editing technology allows researchers to make specific changes to the genetic code of cells and organisms. Jennifer Doudna, PhD, Professor at UC-Berkeley and Executive Director of the Innovative Genomics Initiative (IGI), is one of the pioneers of the technique. 3D Molecular Designs designed and built the model for Dr. Doudna with Jacob Corn, PhD, Scientific Director of the IGI. The front segment of the 5'' plaster model (white) detaches, allowing students a closer look at the guide RNA (orange) and two strands of DNA (light blue and dark blue) inside. The green section is the Protospacer Adjacent Motif, a specific sequence of 3-5 DNA nucleotides known as the PAM sequence. The PAM sequence must be present in double-stranded DNA in order for the cas9 protein to cut the DNA properly.

Animations and Videos

Jennifer Doudna, PhD, explains the CRISPR/Cas9 gene editing technique. One of the technique's pioneers, Dr. Doudna is Executive Director of IGI and Professor at UC Berkeley. More...

Molecule of the Month

The Molecule of the Month by scientist, author and artist Dr. David Goodsell includes an introduction to the structure and function of the chosen molecule and a discussion of its relevance to human health and welfare. Molecule of the Month articles are frequently referred to by teachers, students and researchers. More...